Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a significant risk factor for the development and progression of type I endometrial cancer (EC). Currently, it is not known whether metformin has a direct effect on the endometria and further regulates glycolysis and mitochondrial function in PCOS patients with endometrial hyperplasia and carcinoma. Here we show that endometria from PCOS patients with endometrial hyperplasia and carcinoma have a distinct protein expression pattern of glycoly...

Introduction: Type 2 diabetes mellitus (T2DM) has the same risk of cardiovascular event with coronary artery disease (CAD). Men with diabetes are characterized by a decrease in circulating testosterone concentrations, and testosterone deficiency have been associated with increased risk of metabolic syndrome and CAD. With the increased popularity of western life style in China, the morbidity of T2DM increased greatly in young Chinese people. This study aimed to investigate the ...

Objective: To investigate the effects of C1q/TNF related protein 3 CTRP3 on the insulin sensitivity of adipocyte and its possible mechanisms.Methods: The insulin resistance model of 3T3-L1 adipocyte was induced by palmic acid (PA) cultivation. Such adipocytes were treated with different concentration of recombinant CTRP3 (0,10,50,250,1250 ng/ml) for 12 h, and for different time (2, 6, 12, 24 h) at the concentration of 250 ng/ml. The glucose consumption w...

Objective: To investigate the impact of the serum testosterone on the metabolic syndrome (MS) in young and middle-aged men with type 2 diabetes mellitus (T2DM).Methods: A total of 220 young-and middle-aged (18–50) men with T2DM were recruited in this study and were divided into four groups based on serum testosterone quartile. General information, smoking history and anthropometry data were collected. Fasting glucose, fasting insulin, blood fat and ...

Aim: To investigate the ralationship between semen parameters and serum follicale-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin (PRL) in a group of Chinese men with congenital absence of vas deferens (CAVD).Methods: Ninety patients with CAVD were investigated. During the physical examination the body hair distribution, testicular size, epididymides and vas deferens were carefully inspected and palpated. Semen analysis i...